S100A8 / S100A9（MRP（8/14）是一種鈣結(jié)合蛋白，由中性粒細(xì)胞和單核細(xì)胞分泌而成，糞便中S100A8 / S100A9是贅生性和炎癥性胃腸疾病的標(biāo)志物，一般情況下很難區(qū)分腸易激綜合癥和慢性炎癥性腸病，所以很多時(shí)候會(huì)導(dǎo)致廣泛和不必要結(jié)腸鏡檢查，而S100A8 / S100A9檢測可以使兩組患者明確區(qū)分。將該標(biāo)記物與結(jié)腸直腸癌的標(biāo)準(zhǔn)糞便潛血篩查進(jìn)行比較，能夠清楚地證明了糞便S100A8 / S100A9測試的診斷優(yōu)勢，該參數(shù)具有較高的診斷價(jià)值：如果糞便中的S100A8 / S100A9水平較低，則很可能不存在器質(zhì)性疾病。

Immundiagnostik（IDK）公司能提供大/小鼠鈣結(jié)合蛋白S100A8/S100A9檢測試劑盒（酶聯(lián)免疫法） ，用于定量大/小鼠糞便、血清、尿液、組織提取液及細(xì)胞培養(yǎng)上清液中的S100A8/S100A9(鈣衛(wèi)蛋白MRP8/14 )。

1. Hildebrand, F. et al., 2013. Inflammation-associated enterotypes, host genotype, cage and inter-individual effects drive gut microbiota variation in common laboratory mice. Genome biology, 14(1), p.R4.
2. Nelson, D. a et al., 2012. An expanded myeloid derived suppressor cell population does not play a role in gammaherpesvirus-exacerbated breast cancer metastases. Infectious agents and cancer, 7(1), p.22. Manual S100A8/S100A9 (MRP8/14) 24
3. Prinzen, C. et al., 2009. Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice. BMC genomics, 10, p.66.
4. Soro-Paavonen, A. et al., 2008. Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes. Diabetes, 57(9), pp.2461–2469.
5. Volz, H.C. et al., 2012. S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling. Basic research in cardiology, 107(2), p.250.
6. Wiechert, L. et al., 2012. Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment. Cell communication and signaling : CCS, 10(1), p.40.
7. Yamamoto, Y. et al., 2011. Septic shock is associated with receptor for advanced glycation end products ligation of LPS. Journal of immunology (Baltimore, Md. : 1950), 186(5), pp.3248–57.

北京西美杰科技有限公司為Immundiagnostik（IDK）中國代理，為客戶提供完善的技術(shù)支持與售后服務(wù)。歡迎撥打西美杰客服電話400-050-4006或者登陸網(wǎng)站